TMC-SNPdb: A pilot attempt to fill the gap of lack of Indian specific dbSNP. TMC-SNPdb is first open source freely available, flexible and upgradable SNP database from whole exome data of 62 normal samples derived from cancer patients (hosted at ANNOVAR) from India. It consists of 114, 309 unique germline variants prevalent exclusively among Indian population at variant frequency. TMC-SNPdb comes along with a companion subtraction tool that can be executed with command line option or using an easy-to-use graphical user interface (GUI) to deplete Indian population specific SNPs, in addition to the dbSNP and 1000 Genomes Project.